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KMID : 0043320110340010091
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Archives of Pharmacal Research
2011 Volume.34 No. 1 p.91 ~ p.97
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Polyozellin blocks tumor necrosis factor α-induced interleukin 8 and matrix metalloproteinase 7 production in the human intestinal epithelial cell line HT-29
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Lee Sung-Hee
Song Kyung-Sik
Sohn Dong-Hwan
Seo Geom-Seog
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Abstract
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Polyozellin isolated from Polyozellus multiplex (Thelephoraceae) displays potent anti-inflammatory effects in murine macrophages. Here we evaluated whether polyozellin has the potential to ameliorate diseases characterized by mucosal inflammation in intestinal epithelial HT-29 cells. Polyozellin significantly inhibited tumor necrosis factor (TNF)-α-induced interleukin-8 secretion and mRNA expression. Moreover, polyozellin suppressed the expression of matrix metalloproteinase-7 mRNA and extracellular pro-matrix metalloproteinase-7 secretion. A signal transduction study revealed that polyozellin significantly attenuates TNF-α-mediated p38 phosphorylation, inhibitory factor κBα degradation, and nuclear factor-κB-mediated transcriptional activation. Collectively, these results suggest that polyozellin has the potential to attenuate intestinal inflammation and shed light on the novel signal pathway evoked by TNF-α during intestinal inflammation.
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KEYWORD
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Polyozellin, Tumor necrosis factor-α, Interleukin-8, Matrix metalloproteinase-7, p38, Nuclear factor-κB, Intestinal inflammation
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